Results indicated that nicotine withdrawal exacerbates the behavioral signs of anxiety through alteration of the brain oxidative stress balance, inflammatory response and serotonin metabolism. Moreover, we found that omega 3 pre-treatment significantly prevents the nicotine withdrawal-induced complications by restoration of changes in the mentioned biochemical indices. »
En d’autres mots les acides gras polyinsaturés (n-3) aideraient pour prévenir les symptômes de sevrage de la nicotine et de l’alcohol. Il semble de plus que la diminution de l’anxiété subjective est dépendante en fonction de la dose utilisée.
Bibliographie
- Amiry GY, Haidary M, Azhdari-Zarmehri H, Beheshti F, Ahmadi-Soleimani SM. Omega-3 fatty acids prevent nicotine withdrawal-induced exacerbation of anxiety and depression by affecting oxidative stress balance, inflammatory response, BDNF and serotonin metabolism in rats. Eur J Pharmacol. 2023 May 15;947:175634. doi: 10.1016/j.ejphar.2023.175634. Epub 2023 Mar 1. PMID: 36868293.
- hi Z, Xie Y, Ren H, He B, Wang M, Wan JB, Yuan TF, Yao X, Su H. Fish oil treatment reduces chronic alcohol exposure induced synaptic changes. Addict Biol. 2019 Jul;24(4):577-589. doi: 10.1111/adb.12623. Epub 2018 Mar 22. PMID: 29569345.
Mots clés
nicotine, acide gras polyinsaturés, EPA, binge drinking