Utilisateur:JackBortone/Research/Topics/Glyphosate

Abstract

How can we trust the science if we can't be sure that it's independent?

Brainstorming

• Glyphosate residues in food : Taking control of your EPSP synthase because we can!! :-)
• HSV2 : Experimental evidences suggests increasing levels of Lysine may prevent PRMT-mediated cell replication in cancer and diseases. (ie: CDKs, Cyclin D1...)

Experimental

Lysine is a competitive substrate of EPSP synthase

• IMPORTANT UPDATE : Lysine (pyruvate kinase/PEP) is a competitive (first-order) substrate of 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase. [1]

Role of and functions of glyphosate analogues in arginine methyltransferase (PMRTs) mediated cell replication

Please review :

1. Protein arginine methylation: an emerging regulator of the cell cycle. [2]
2. Cyclins and cell cycle control in cancer and diseases. [3]

Female-specific reproductive disorders

• [insert problem here....]

Male-specific reproductive disorders

• spermatogenesis
• prostate cancer
• testosterone (glyphosate is a estrogenic agent.)
• [insert problem here....]

Characterization of glyphosate-induced metabolic phenotype

• Note 1
• Note 2

References

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29264/

   Interaction of the herbicide glyphosate with its target enzyme 5-enolpyruvylshikimate 3-phosphate synthase in atomic detail.

2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859524/

   Protein arginine methylation: an emerging regulator of the cell cycle.

3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636749/

   Cyclins and Cell Cycle Control in Cancer and Disease.

4. https://www.ncbi.nlm.nih.gov/pubmed/23820267

   Roundup disrupts male reproductive functions by triggering calcium-mediated cell death in rat testis and Sertoli cells.

5. https://academic.oup.com/toxsci/advance-article-abstract/doi/10.1093/toxsci/kfz039/5345574?redirectedFrom=fulltext

   Perinatal exposure to glyphosate and a glyphosate-based herbicide affect spermatogenesis in mice.

6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838446/

   Lysine metabolism in mammalian brain: an update on the importance of recent discoveries

7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2322953/

   Metabolic responses to pyruvate kinase deletion in lysine producing Corynebacterium glutamicum.

8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794935/

   Lysine 269 is essential for cyclin D1 ubiquitylation by the SCFFbx4/αB-crystallin ligase and subsequent proteasome-dependent degradation