Utilisateur:JackBortone/2020/05/13

Brainstorming

Burkholderia cepacia complex (Bcc) -> BclA (H. sapiens!)

Concepts: Complement System, Sugar binding proteins, Glycoproteins, Glycolysation

Bacterial (C-type) Lectins (mannose, fucose, DC-SIGN)

O-linked glycans

HA1.... (TNF-Like Fold) -> https://www.rcsb.org/structure/2WQ4

Human-specific blood type O

https://www.rcsb.org/structure/1WCK

References

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521585/

   Pilus biogenesis of Gram‐positive bacteria: Roles of sortases and implications for assembly

2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718342/

   Sortase Transpeptidases: Structural Biology and Catalytic Mechanism

3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331890/

   Activation of the Classical Complement Pathway by Bacillus anthracis is the Primary Mechanism for Spore Phagocytosis and Involves the Spore Surface Protein BclA

4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929507/

   Burkholderia cepacia Complex: Emerging Multihost Pathogens Equipped with a Wide Range of Virulence Factors and Determinants

5. https://www.jbc.org/content/early/2016/02/26/jbc.M116.718171

   Glycosylation of BclA glycoprotein from Bacillus cereus and Bacillus anthracis exosporium is domain specific

6. https://www.ncbi.nlm.nih.gov/pubmed/29669880

   Transmembrane Domains of Highly Pathogenic Viral Fusion Proteins Exhibit Trimeric Association In Vitro.

7. https://www.jbc.org/content/280/52/43073

   The Crystal Structure of the Bacillus anthracis Spore Surface Protein BclA Shows Remarkable Similarity to Mammalian Proteins