Utilisateur:JackBortone/Research/Topics/Cannabis
Endocannabinoid research
The neurocomputational aspects of endocannabinoid-based neuroprotection has emerged as a mature research area. My current research aim to investigate experimental methods for exploiting the endocannabinoid levels for neuroprotection purpose. In particular, the study of retrograde signaling (anandamide trafficking) can be helpful to understand how on-demand anandamide mobilization fine-tune dopamine receptors availability, density, and connectivity in the PFC, striatum, and microglia.
Furthermore, the study of endocannabinoid-mediated synaptic hypercomputation is under investigation. In specific, the role and mecanism of intracellular CB1 activation in the regulation of synchronized gamma-band oscillations (neuronal phase coherence?) by dopamine is poorly documented.
Retrograde signaling neurodynamics
Notebook:
Research subtopics:
- Eicosanoids synthesis
- Microglial/dopamine neuroprotection
- energy expenditure of endocannabinoid-mediated cellular homeostasis
Synaptogenic effects of DHA-5-HT, a putative endocannabinoid transporter
Notebook:
Research subtopics:
- DHA-5-HT signaling
- Intracellular signal transduction pathways of synaptamide
- P2X7 receptor pharmacodynamics
See also:
Neuroprotective effects of cannabinoids for traumatic brain injury and drug-induced neuronal damage
Intracellular CB1 activation by cannabinoids (THC) may mediate monoaminergic cross-talk and GPCR receptor heteromization, a potential neuroprotective mecanism for drug-induced neuronal damage.
On-demand programming of neural stem cells by anandamide trafficking
Anandamide trafficking may activate AKT1/CREB signaling (phosphorylation) in the brain.
Anandamide/AKT signaling
- AKT1 Notebook
- Review: The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt.